Nitric oxide,
also known as nitrogen monoxide, is a highly unstable
poisonous gas that, paradoxically, is vital to the health of humans and
most other mammals. A byproduct of nitric acid production and human
metabolic processes, nitric oxide is highly toxic. Exposure in high
enough concentration can prove fatal. Despite its highly toxic nature,
nitric oxide has several proved medicinal benefits.
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Nitric oxide produced by the human body plays an important
role as a vasodilator. Its presence helps relax blood vessels and
improves blood flow, reducing blood pressure. Additionally, nitric oxide
helps to impede blood clotting within blood vessels, which helps fend
off dangerous clots that can cause clogged arteries and lead to heart
attack or stroke.
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The presence of nitric oxide in the body helps stimulate the
growth in size and number of the body's mitochondria. Mitochondria are
special organelles found in most of the body's cells that are
responsible for producing the energy the human body runs on. The larger
and more numerous they are, the faster a cell's metabolism. While nitric
oxide is only present in very small amounts, it is critical to keeping
the cell's metabolism running correctly.
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Nitric oxide acts as a messenger chemical within the body,
assisting the immune system in seeking out and destroying invading
bacteria, viruses and parasites. Additionally, nitric oxide disables the
mitochondria of virus-infected cells. This kills the infected cells and
and the virus that inhabits them.
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The role of nitric oxide in fighting and preventing cancer
is still being researched. Current research shows that nitric oxide
helps to destroy cancerous cells by deactivating respiratory chain
enzymes in the cells' mitochondria, causing cellular death. The death of
the cancerous cells helps to keep tumors from growing and spreading.
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Currently nitric oxide, marketed under the trade name
INOmax, is administered in gaseous form to premature infants as a
treatment for respiratory failure. Other clinical uses include treatment
of pulmonary hypertension and hypoxemia following cardiopulmonary
bypass, asthma and bronchospastic disease and sickle cell anemia.
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